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Thromb Haemost. 2000 Apr;83(4):589-91.

The thrombogram: monitoring thrombin generation in platelet-rich plasma.

Author information

  • 1Department of Biochemistry and Synapse BV, Cardiovascular Research Institute (CARIM) Maastricht, The Netherlands. Coen.Hemker@thrombin.com


A method is described in which thrombin activity in clotting plasma can be monitored through the continuous measurement of the fluorescent split-product of the substrate Z-Gly-Gly-Arg-AMC. The signal is not impaired by turbidity; therefore proper measurement is not disturbed by the occurrence of a clot or the presence of platelets and direct measurement in platelet rich plasma is possible.

[PubMed - indexed for MEDLINE]
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