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Genome Res. 2000 Apr;10(4):547-8.

Using GeneWise in the Drosophila annotation experiment.

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  • 1Sanger Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK. Birney@ebi.ac.uk

Abstract

The GeneWise method for combining gene prediction and homology searches was applied to the 2.9-Mb region from Drosophila melanogaster. The results from the Genome Annotation Assessment Project (GASP) showed that GeneWise provided reasonably accurate gene predictions. Further investigation indicates that many of the incorrect gene predictions from GeneWise were due to transposons with valid protein-coding genes and the remaining cases are pseudogenes or possible annotation oversights.

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PMID:
10779496
[PubMed - indexed for MEDLINE]
PMCID:
PMC310858
Free PMC Article
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