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Annu Rev Med. 2000;51:423-30.

The spectrum of human herpesvirus 6 infection: from roseola infantum to adult disease.

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  • 1Weil Medical College of Cornell University, New York, New York 10021, USA.


Human herpesvirus 6 is the causative agent of roseola infantum, a generally benign rash illness of infants. Most persons acquire HHV-6 infection by age 2 years, and HHV-6 infection is a common cause of fever and febrile seizures in infants. In adults, primary infection with HHV-6 can produce a mononucleosis-like illness and, more rarely, severe disease, including encephalitis. In addition to primary infections, HHV-6 can cause clinical illness during reactivation, particularly in immunocompromised persons.

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