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Cytogenet Cell Genet. 2000;88(1-2):159-62.

Characterization of a new TSPY gene family member in Yq (TSPYq1).

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  • 1Istituto di Clinica Neurologica, Universit√† di Milano, Ospedale Policlinico IRCCS, Chieti (Italy).


We investigated subinterval 6E on the human Y chromosome, a region frequently deleted in infertile males. YAC yOX17, mapped within subinterval 6E by STS-PCR, was analyzed for the presence of new genes. TSPYq1, a member of the TSPY multi-copy gene family, was isolated and characterized from a yOX17 cosmid subclone. PCR and FISH analysis performed on normal subjects and on patients with microdeletions of Yq suggested the presence of multiple copies of TSPY in Yq.

Copyright 2000 S. Karger AG, Basel

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