Format

Send to

Choose Destination
See comment in PubMed Commons below
Biochim Biophys Acta. 2000 Apr 17;1496(2-3):151-63.

The sevenless signaling pathway: variations of a common theme.

Author information

  • 1Department of Genetics, University of Würzburg, Biozentrum, Am Hubland, D-97074, Würzburg, Germany. raabe@biozentrum.uni-wuerzburg.de

Abstract

Many developmental processes are regulated by intercellular signaling mechanisms that employ the activation of receptor tyrosine kinases. One model system that has been particular useful in determining the role of receptor tyrosine kinase-mediated signaling processes in cell fate determination is the developing Drosophila eye. The specification of the R7 photoreceptor cell in each ommatidium of the developing Drosophila eye is dependent on activation of the Sevenless receptor tyrosine kinase. This review will focus on the genetic and biochemical approaches that have identified signaling molecules acting downstream of the Sevenless receptor tyrosine kinase which ultimately trigger differentiation of the R7 photoreceptor cell.

PMID:
10771085
[PubMed - indexed for MEDLINE]
Free full text

LinkOut - more resources

Full Text Sources

Molecular Biology Databases

PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk