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J Acquir Immune Defic Syndr. 1999 Nov 1;22(3):253-9.

Randomized, controlled trial of caloric supplements in HIV infection. Terry Beirn Community Programs for Clinical Research on AIDS.

Author information

  • 1Veteran Affairs Medical Center, Washington Regional AIDS Program, DC 20422, USA. gibert.c@washington.va.gov

Abstract

OBJECTIVE:

To compare the efficacy of three nutritional regimens in the prevention of weight loss.

DESIGN:

A three-arm randomized controlled trial with primary outcome measure percent change in weight over four months.

PATIENTS:

A total of 536 patients with CD4 count <200 cells/mm3 and stable weight, defined as <5% weight loss as determined by a weight measurement 3 to 6 months before randomization were recruited at fourteen administrative units in the United States, each unit consisting of multiple primary care sites.

INTERVENTION:

The three arms were 500 kcal daily of caloric supplement with peptides and medium-chain triglycerides plus a multivitamin and mineral supplement, 500 kcal of a caloric supplement with whole protein and long-chain triglycerides plus a multivitamin and mineral supplement, and a multivitamin and mineral supplement only.

RESULTS:

There were no significant differences among the three regimens in the percent change in weight (p = .74) and body cell mass (p = .63). On average, 65% of the recommended 500 kcal/day of caloric supplements containing peptides with medium-chain triglycerides and 82% of the 500 kcal/day of the caloric supplement containing whole protein and long-chain triglycerides were consumed.

CONCLUSIONS:

Caloric supplements do not promote increases in average weight or body cell mass in weight-stable, HIV-infected adults beyond that offered by a multivitamin and mineral supplement.

PMID:
10770345
[PubMed - indexed for MEDLINE]
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