Your browser version may not work well with NCBI's Web applications. More information here...
1: J Bacteriol. 2000 May;182(9):2668-71.Click here to read Click here to read Links

Equivalence of lauric acid and glycerol monolaurate as inhibitors of signal transduction in Staphylococcus aureus.

Ruzin A, Novick RP.

New York University Medical Center, Skirball Institute, New York, New York 10016, USA.

Glycerol monolaurate (GML) inhibits the expression of virulence factors in Staphylococus aureus and the induction of vancomycin resistance in Enterococcus faecalis, presumably by blocking signal transduction. Although GML is rapidly hydrolyzed by bacteria, one of the products, lauric acid, has identical inhibitory activity and is metabolized much more slowly. At least four distinct GML-hydrolyzing activities are identified in S. aureus: the secreted Geh lipase, residual supernatant activity in a geh-null mutant strain, a novel membrane-bound esterase, and a cytoplasmic activity.

PMID: 10762277 [PubMed - indexed for MEDLINE]

PMCID: PMC111339

Patient Drug Information

  • Vancomycin (Vancocin® )

    Vancomycin is used to treat colitis (inflammation of the intestine caused by certain bacteria) that may occur after antibiotic treatment. Vancomycin is in a class of medications called glycopeptide antibiotics. It works ...

  • Source: AHFS Consumer Medication Information