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Bioorg Med Chem Lett. 2000 Apr 3;10(7):657-60.

Isoniazid-related copper(II) and nickel(II) complexes with antimycobacterial in vitro activity. Part 9.

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  • 1Dipartimento Farmaco-chimico, Facoltà di Farmacia, Università di Messina, Italy.


Isonicotinoylhydrazones 1, obtained by the primary antituberculous agent Isoniazid, have been used as monoanionic ligands (L) to prepare copper(II) 2 and nickel(II) 3 octahedral complexes of stoichiometry [MeL2(H2O)2]. Their antimycobacterial in vitro activity was evaluated against Mycobacterium tuberculosis H37Rv in comparison with the ligands. Complexes 2a, 2b, 2f, 3b, 3d and 3g displayed MIC values < or = 0.2 microg/mL.

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