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Arch Intern Med. 2000 Apr 10;160(7):939-44.

Effect of smoking cessation on mortality after myocardial infarction: meta-analysis of cohort studies.

Author information

  • 1Department of Medicine, McMaster University, Hamilton, Ontario, Canada. kwilson@lri.ca

Abstract

OBJECTIVE:

To determine the effect of smoking cessation on mortality after myocardial infarction.

DATA SOURCES:

English- and non-English-language articles published from 1966 through 1996 retrieved using keyword searches of MEDLINE and EMBASE supplemented by letters to authors and searching bibliographies of reviews.

STUDY SELECTION:

Selection of relevant abstracts and articles was performed by 2 independent reviewers. Articles were chosen that reported the results of cohort studies examining mortality in patients who quit vs continued smoking after myocardial infarction.

DATA EXTRACTION:

Mortality data were extracted from the selected articles by 2 independent reviewers.

DATA SYNTHESIS:

Twelve studies were included containing data on 5878 patients. The studies took place in 6 countries between 1949 and 1988. Duration of follow-up ranged from 2 to 10 years. All studies showed a mortality benefit associated with smoking cessation. The combined odds ratio based on a random effects model for death after myocardial infarction in those who quit smoking was 0.54 (95% confidence interval, 0.46-0.62). Relative risk reductions across studies ranged from 15% to 61%. The number needed to quit smoking to save 1 life is 13 assuming a mortality rate of 20% in continuing smokers. The mortality benefit was consistent regardless of sex, duration of follow-up, study site, and time period.

CONCLUSION:

Results of several cohort studies suggest that smoking cessation after myocardial infarction is associated with a significant decrease in mortality.

PMID:
10761958
[PubMed - indexed for MEDLINE]
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