Br J Gen Pract. 1999 Sep;49(446):745-9.

The newer, 'atypical' antipsychotic drugs--their development and current therapeutic use.

Source

University of Southampton, Aldermoor Health Centre. ark1@soton.ac.uk

Abstract

General practitioners (GPs) need to become more aware of a new generation of antipsychotic drugs that are 'atypical' in that, unlike traditional neuroleptics, they do not cause extrapyramidal side-effects; they may also be more effective against both the positive and negative symptoms of schizophrenia by their actions on various neurotransmitter pathways in the brain. This is a non-systematic review of the development of these new drugs and outlines how they are currently being used. It includes information found from an electronic search of the databases MEDLINE (from 1966 to June 1998) and EMBASE (from 1980 to January 1998) using the combined search terms 'antipsychotic agents', 'atypical', and 'schizophrenia'.

PMID:: 10756621; [PubMed - indexed for MEDLINE]
PMCID:: PMC1313507

Free PMC Article

Publication Types, MeSH Terms, Substances

Publication Types

Review

MeSH Terms

Substances

Antipsychotic Agents

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Schizophrenia - MedlinePlus Health Information

Supplemental Content

Save items

Related citations in PubMed

Review Amisulpride for schizophrenia. [Cochrane Database Syst Rev. 2002]
Review Amisulpride for schizophrenia.
Mota NE, Lima MS, Soares BG. Cochrane Database Syst Rev. 2002; (2):CD001357.
Review Sertindole for schizophrenia. [Cochrane Database Syst Rev. 2005]
Review Sertindole for schizophrenia.
Lewis R, Bagnall AM, Leitner M. Cochrane Database Syst Rev. 2005 Jul 20; (3):CD001715. Epub 2005 Jul 20.
Review Newer atypical antipsychotic medication versus clozapine for schizophrenia. [Cochrane Database Syst Rev. 2000]
Review Newer atypical antipsychotic medication versus clozapine for schizophrenia.
Tuunainen A, Wahlbeck K, Gilbody SM. Cochrane Database Syst Rev. 2000; (2):CD000966.
Randomised controlled trials of conventional antipsychotic versus new atypical drugs, and new atypical drugs versus clozapine, in people with schizophrenia responding poorly to, or intolerant of, current drug treatment. [Health Technol Assess. 2006]
Randomised controlled trials of conventional antipsychotic versus new atypical drugs, and new atypical drugs versus clozapine, in people with schizophrenia responding poorly to, or intolerant of, current drug treatment.
Lewis SW, Davies L, Jones PB, Barnes TR, Murray RM, Kerwin R, Taylor D, Hayhurst KP, Markwick A, Lloyd H, et al. Health Technol Assess. 2006 May; 10(17):iii-iv, ix-xi, 1-165.
Review Molindone for schizophrenia and severe mental illness. [Cochrane Database Syst Rev. 2000]
Review Molindone for schizophrenia and severe mental illness.
Bagnall A, Fenton M, Lewis R, Leitner ML, Kleijnen J. Cochrane Database Syst Rev. 2000; (2):CD002083.

See reviews... See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Free in PMC
Free full text articles in PMC

Recent activity

Clear Turn Off Turn On

The newer, 'atypical' antipsychotic drugs--their development and current therape...
The newer, 'atypical' antipsychotic drugs--their development and current therapeutic use.
Br J Gen Pract. 1999 Sep ;49(446):745-9.

PubMed
DNA strand transfer catalyzed by vaccinia topoisomerase: ligation of DNAs contai...
DNA strand transfer catalyzed by vaccinia topoisomerase: ligation of DNAs containing a 3' mononucleotide overhang.
Nucleic Acids Res. 2000 May 1 ;28(9):1893-8.

PubMed
The role of alpha/beta and gamma interferons in development of immunity to influ...
The role of alpha/beta and gamma interferons in development of immunity to influenza A virus in mice.
J Virol. 2000 May ;74(9):3996-4003.

PubMed
Genomic medicine and the future of health care.
Genomic medicine and the future of health care.
Science. 2000 Mar 17 ;287(5460):1977-8.

PubMed
Memory disturbances in "Ecstasy" users are correlated with an altered brain sero...
Memory disturbances in "Ecstasy" users are correlated with an altered brain serotonin neurotransmission.
Psychopharmacology (Berl). 2000 Feb ;148(3):322-4.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: