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Curr Opin Struct Biol. 2000 Apr;10(2):236-41.

Focusing-in on microtubules.

Author information

  • MRC Laboratory of Molecular Biology, Cambridge, CB2 2QH, UK. laa@mrc-lmb.cam.ac.uk

Abstract

A good approximation of the atomic structure of a microtubule has been derived from docking the high-resolution structure of tubulin, solved by electron crystallography, into lower resolution maps of whole microtubules. Some structural interactions with other molecules, including nucleotides, drugs, motor proteins and microtubule-associated proteins, can now be predicted.

PMID:
10753804
[PubMed - indexed for MEDLINE]
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