Format

Send to

Choose Destination
See comment in PubMed Commons below
Curr Opin Genet Dev. 2000 Apr;10(2):144-50.

DNA double strand break repair in mammalian cells.

Author information

  • 1Clare Hall Laboratories, Imperial Cancer Research Fund, South Mimms, EN6 3LD, UK. karran@icrf.icnet.uk

Abstract

Human cells can process DNA double-strand breaks (DSBs) by either homology directed or non-homologous repair pathways. Defects in components of DSB repair pathways are associated with a predisposition to cancer. The products of the BRCA1 and BRCA2 genes, which normally confer protection against breast cancer, are involved in homology-directed DSB repair. Defects in another homology-directed pathway, single-strand annealing, are associated with genome instability and cancer predisposition in the Nijmegen breakage syndrome and a radiation-sensitive ataxia-telangiectasia-like syndrome. Many DSB repair proteins also participate in the signaling pathways which underlie the cell's response to DSBs.

PMID:
10753787
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk