Format

Send to:

Choose Destination
See comment in PubMed Commons below
Curr Opin Genet Dev. 2000 Apr;10(2):151-6.

Replication and recombination intersect.

Author information

  • 1Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA. k-marians@ski.mskcc.org

Abstract

A bacterial housekeeping function, which requires both recombination and replication enzymes, has been identified that re-establishes inactivated replication forks under normal growth conditions. Some long-tract gene-conversion events initiated by double-strand breaks in yeast and mammalian cells can be attributed to recombination-directed DNA replication. Double-strand break repair in yeast has been shown to require both leading- and lagging-strand DNA synthesis. These observations suggest that the recombination and replication machinery cooperate to maintain genomic integrity.

PMID:
10753777
[PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

Molecular Biology Databases

PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk