Curr Biol. 2000 Apr 6;10(7):R260-4.

Protein folding: versatility of the cytosolic chaperonin TRiC/CCT.

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Department of Cellular Biochemistry, Max-Planck-Institut für Biochemie, Martinsried, D-82152, Germany.

Abstract

Efficient de novo folding of actins and tubulins requires two molecular chaperones, the chaperonin TRiC (or CCT) and its novel cofactor GimC (or prefoldin). Recent studies indicate that TRiC is exquisitely adapted for this task, yet has the ability to interact with and assist the folding of numerous other cellular proteins.

PMID:: 10753735; [PubMed - indexed for MEDLINE]

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Review Structure and function of a protein folding machine: the eukaryotic cytosolic chaperonin CCT. [FEBS Lett. 2002]
Review Structure and function of a protein folding machine: the eukaryotic cytosolic chaperonin CCT.
Valpuesta JM, Martín-Benito J, Gómez-Puertas P, Carrascosa JL, Willison KR. FEBS Lett. 2002 Oct 2; 529(1):11-6.
Structure of eukaryotic prefoldin and of its complexes with unfolded actin and the cytosolic chaperonin CCT. [EMBO J. 2002]
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Martín-Benito J, Boskovic J, Gómez-Puertas P, Carrascosa JL, Simons CT, Lewis SA, Bartolini F, Cowan NJ, Valpuesta JM. EMBO J. 2002 Dec 2; 21(23):6377-86.
Review The role of molecular chaperones in human misfolding diseases. [FEBS Lett. 2009]
Review The role of molecular chaperones in human misfolding diseases.
Broadley SA, Hartl FU. FEBS Lett. 2009 Aug 20; 583(16):2647-53. Epub 2009 Apr 23.
TRiC/CCT cooperates with different upstream chaperones in the folding of distinct protein classes. [EMBO J. 2003]
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Siegers K, Bölter B, Schwarz JP, Böttcher UM, Guha S, Hartl FU. EMBO J. 2003 Oct 1; 22(19):5230-40.
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Melville MW, McClellan AJ, Meyer AS, Darveau A, Frydman J. Mol Cell Biol. 2003 May; 23(9):3141-51.

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Cited by 23 PubMed Central articles

Functional Subunits of Eukaryotic Chaperonin CCT/TRiC in Protein Folding. [J Amino Acids. 2011]
Functional Subunits of Eukaryotic Chaperonin CCT/TRiC in Protein Folding.
Kabir MA, Uddin W, Narayanan A, Reddy PK, Jairajpuri MA, Sherman F, Ahmad Z. J Amino Acids. 2011; 2011:843206. Epub 2011 Jul 2.
The protein interaction network of the human transcription machinery reveals a role for the conserved GTPase RPAP4/GPN1 and microtubule assembly in nuclear import and biogenesis of RNA polymerase II. [Mol Cell Proteomics. 2010]
The protein interaction network of the human transcription machinery reveals a role for the conserved GTPase RPAP4/GPN1 and microtubule assembly in nuclear import and biogenesis of RNA polymerase II.
Forget D, Lacombe AA, Cloutier P, Al-Khoury R, Bouchard A, Lavallée-Adam M, Faubert D, Jeronimo C, Blanchette M, Coulombe B. Mol Cell Proteomics. 2010 Dec; 9(12):2827-39. Epub 2010 Sep 20.
4.0-A resolution cryo-EM structure of the mammalian chaperonin TRiC/CCT reveals its unique subunit arrangement. [Proc Natl Acad Sci U S A. 2010]
4.0-A resolution cryo-EM structure of the mammalian chaperonin TRiC/CCT reveals its unique subunit arrangement.
Cong Y, Baker ML, Jakana J, Woolford D, Miller EJ, Reissmann S, Kumar RN, Redding-Johanson AM, Batth TS, Mukhopadhyay A, et al. Proc Natl Acad Sci U S A. 2010 Mar 16; 107(11):4967-72. Epub 2010 Mar 1.

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