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Curr Opin Lipidol. 2000 Feb;11(1):25-9.

The value of apolipoprotein E knockout mice for studying the effects of dietary fat and cholesterol on atherogenesis.

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  • 1Departamento de Bioquímica y Biología Molecular y Celular, Facultad de Veterinaria, Universidad de Zaragoza, Spain.


The ability of the apolipoprotein E-deficient mouse to develop spontaneous atherosclerosis, which resembles the human process, is an excellent model in which to assess the impact of dietary factors. This review discusses the role of several nutrients in the development of atherosclerosis and the mechanisms through which they act.

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