Acta Virol. 1999 Aug;43(4):237-44.

An epitope shared by the hemagglutinins of H1, H2, H5, and H6 subtypes of influenza A virus.

Smirnov YA, Lipatov AS, Gitelman AK, Okuno Y, Van Beek R, Osterhaus AD, Claas EC.

Source

The D.I. Ivanovsky Institute of Virology, Russian Academy of Medical Sciences, Moscow. smirnov@invir.msk.su

Abstract

The membrane-inserted hemagglutinin (HA) is the most variable protein of influenza viruses. Here we describe the characterization of a shared epitope in the HA of influenza A virus H1, H2, and H5 subtypes which were completely neutralized by a monoclonal antibody (MAb), directed against this epitope. This MAb (C179) also efficiently precipitated the HAs of these viruses. In addition, MAb C179 did not neutralize H6 subtype strains despite complete amino acid homology of the epitope regions. Furthermore, only the non-glycosylated form of the HA of one of the H6 subtype strains could be precipitated by the MAb. The conformational epitope may be masked by glycosylation, although it could not be excluded that differences in the primary amino acid sequence may cause the decreased accessibility of the epitope in H6 subtype strains.

PMID:: 10749369; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Supplemental Content

Save items

Related citations in PubMed

[A common antigenic epitope in influenza A virus (H1, H2, H5, H6) hemagglutinin]. [Vopr Virusol. 1999]
[A common antigenic epitope in influenza A virus (H1, H2, H5, H6) hemagglutinin].
Smirnov IuA, Lipatov AS, Okuno I, Gitel'man AK. Vopr Virusol. 1999 May-Jun; 44(3):111-5.
Cross-protective potential of a novel monoclonal antibody directed against antigenic site B of the hemagglutinin of influenza A viruses. [PLoS Pathog. 2009]
Cross-protective potential of a novel monoclonal antibody directed against antigenic site B of the hemagglutinin of influenza A viruses.
Yoshida R, Igarashi M, Ozaki H, Kishida N, Tomabechi D, Kida H, Ito K, Takada A. PLoS Pathog. 2009 Mar; 5(3):e1000350. Epub 2009 Mar 20.
Prevention and treatment of bronchopneumonia in mice caused by mouse-adapted variant of avian H5N2 influenza A virus using monoclonal antibody against conserved epitope in the HA stem region. [Arch Virol. 2000]
Prevention and treatment of bronchopneumonia in mice caused by mouse-adapted variant of avian H5N2 influenza A virus using monoclonal antibody against conserved epitope in the HA stem region.
Smirnov YA, Lipatov AS, Gitelman AK, Claas EC, Osterhaus AD. Arch Virol. 2000; 145(8):1733-41.
Review One step closer to universal influenza epitopes. [Expert Rev Anti Infect Ther. 2...]
Review One step closer to universal influenza epitopes.
Li OT, Poon LL. Expert Rev Anti Infect Ther. 2009 Aug; 7(6):687-90.
Review Development and use of fowlpox vectored vaccines for avian influenza. [Ann N Y Acad Sci. 2006]
Review Development and use of fowlpox vectored vaccines for avian influenza.
Bublot M, Pritchard N, Swayne DE, Selleck P, Karaca K, Suarez DL, Audonnet JC, Mickle TR. Ann N Y Acad Sci. 2006 Oct; 1081:193-201.

See reviews... See all...

Cited by 14 PubMed Central articles

Review Induction of virus-specific cytotoxic T lymphocytes as a basis for the development of broadly protective influenza vaccines. [J Biomed Biotechnol. 2011]
Review Induction of virus-specific cytotoxic T lymphocytes as a basis for the development of broadly protective influenza vaccines.
Hillaire ML, Osterhaus AD, Rimmelzwaan GF. J Biomed Biotechnol. 2011; 2011:939860. Epub 2011 Oct 5.
Targets for the induction of protective immunity against influenza a viruses. [Viruses. 2010]
Targets for the induction of protective immunity against influenza a viruses.
Bodewes R, Osterhaus AD, Rimmelzwaan GF. Viruses. 2010 Jan; 2(1):166-88. Epub 2010 Jan 14.
Review Structural basis of influenza virus neutralization. [Ann N Y Acad Sci. 2011]
Review Structural basis of influenza virus neutralization.
Han T, Marasco WA. Ann N Y Acad Sci. 2011 Jan; 1217:178-90. Epub 2011 Jan 11.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Nucleotide
Primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
Taxonomy via GenBank
Taxonomy records associated with the current articles through taxonomic information on related molecular database records (Nucleotide, Protein, Gene, SNP, Structure).
Protein
Protein translation features of primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

An epitope shared by the hemagglutinins of H1, H2, H5, and H6 subtypes of influe...
An epitope shared by the hemagglutinins of H1, H2, H5, and H6 subtypes of influenza A virus.
Acta Virol. 1999 Aug ;43(4):237-44.

PubMed
Role of virtual electrodes in arrhythmogenesis: pinwheel experiment revisited.
Role of virtual electrodes in arrhythmogenesis: pinwheel experiment revisited.
J Cardiovasc Electrophysiol. 2000 Mar ;11(3):274-85.

PubMed
A critical time intervention with mentally ill homeless men: impact on psychiatr...
A critical time intervention with mentally ill homeless men: impact on psychiatric symptoms.
J Nerv Ment Dis. 2000 Mar ;188(3):135-40.

PubMed
Cell biology. Reeling CASK into the nucleus.
Cell biology. Reeling CASK into the nucleus.
Nature. 2000 Mar 16 ;404(6775):241-2.

PubMed
Differential expression of four human dynamin-like protein variants in brain tum...
Differential expression of four human dynamin-like protein variants in brain tumors.
DNA Cell Biol. 2000 Mar ;19(3):189-94.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

An epitope shared by the hemagglutinins of H1, H2, H5, and H6 subtypes of influenza A virus.

Source

Abstract

Publication Types, MeSH Terms, Substances, Secondary Source ID

Publication Types

MeSH Terms

Substances

Secondary Source ID

LinkOut - more resources

Other Literature Sources

Supplemental Content

Save items

Related citations in PubMed

Cited by 14 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information