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Curr Opin Microbiol. 2000 Apr;3(2):165-70.

Two-component and phosphorelay signal transduction.

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  • 1Division of Cellular Biology, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA. hoch@scripps.edu

Abstract

Two-component and phosphorelay signal transduction systems are the major means by which bacteria recognize and respond to a variety of environmental stimuli. Recent results have implicated these systems in the regulation of a variety of essential processes including cell-cycle progression, pathogenicity, and developmental pathways. Elucidation of the structures of the interacting domains is leading to an understanding of the mechanisms of molecular recognition and phosphotransfer in these systems.

PMID:
10745001
[PubMed - indexed for MEDLINE]
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