Cell polarity: Nailing Crumbs to the scaffold

P Rashbass; H Skaer

doi:10.1016/s0960-9822(00)00372-9

Cell polarity: Nailing Crumbs to the scaffold

Curr Biol. 2000 Mar 23;10(6):R234-6. doi: 10.1016/s0960-9822(00)00372-9.

Authors

P Rashbass¹, H Skaer

Affiliation

¹ Developmental Genetics Programme, Krebs Institute, University of Sheffield, Sheffield, S10 2TN, UK.

PMID: 10744962
DOI: 10.1016/s0960-9822(00)00372-9

Abstract

Recent studies suggest that the cytoplasmic tail of the Crumbs protein establishes membrane territories in polarised epithelial cells by stabilising a PDZ-domain protein complex. The isolation of a human Crumbs homologue required for normal vision revives questions about the role of Crumbs in cell-cell interactions.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Alternative Splicing
Animals
Cell Polarity / physiology*
Drosophila Proteins*
Humans
Membrane Proteins / genetics
Membrane Proteins / physiology*
Protein Isoforms / genetics
Protein Isoforms / physiology

Substances

Drosophila Proteins
Membrane Proteins
Protein Isoforms
crb protein, Drosophila