Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Appetite. 2000 Apr;34(2):147-51.

The vagus nerve is involved in the anorexigenic effect of simmondsin in the rat.

Author information

  • 1Interdisciplinary Research Centre, Katholieke Universiteit Leuven, Belgium.

Abstract

Simmondsin, 2-(cyanomethylene)-3 hydroxy 4,5 dimethoxy cyclohexyl beta-D-glucoside, from jojoba meal reduces food intake in rats. We investigated the mechanism of action simmondsin, by studying the effects of fasting or of vagotomy on the food intake reduction. The food intake reduction was significantly less in fasted rats than in non-fasted rats. The reduction of food intake was also significantly diminished after vagotomy. The results of the present experiments suggest that simmondsin reduces intake of food in rats through the augmentation of satiety, in part vagally mediated.

Copyright 2000 Academic Press.

PMID:
10744903
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk