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J Chromatogr B Biomed Sci Appl. 2000 Feb 28;739(1):163-73.

Molecular imprinting for drug bioanalysis. A review on the application of imprinted polymers to solid-phase extraction and binding assay.

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  • 1Bioanalytical Chemistry, AstraZeneca R&D Södertälje, Sweden. lars.i.andersson@astrazeneca.com

Abstract

Molecularly imprinted polymers have been applied as selective sorbents in several analytical techniques, including liquid chromatography, capillary electrophoresis and capillary electrochromatography, solid-phase extraction, and 'immunoassay'. An advantage of this type of sorbent is the possibility to synthesize polymers with selectivity pre-determined for a particular analyte. This review critically discusses the use of imprinted polymers for analysis of drugs and other compounds in biological samples, with emphasis on their use as highly selective solid-phase extraction sorbents for sample pre-concentration and alternative binding entities in immunoassay type protocols.

PMID:
10744324
[PubMed - indexed for MEDLINE]
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