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Nat Med. 2000 Apr;6(4):389-95.

Mechanisms of angiogenesis and arteriogenesis.

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  • 1The Center for Transgene Technology and Gene Therapy Flanders Interuniversity Institute for Biotechnology KU Leuven, Leuven, B-3000, Belgium. peter.carmeliet@med.kuleuven.ac.be

Abstract

Endothelial and smooth muscle cells interact with each other to form new blood vessels. In this review, the cellular and molecular mechanisms underlying the formation of endothelium-lined channels (angiogenesis) and their maturation via recruitment of smooth muscle cells (arteriogenesis) during physiological and pathological conditions are summarized, alongside with possible therapeutic applications.

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