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    Science. 2000 Mar 31;287(5462):2492-3.

    Similar requirements of a plant symbiont and a mammalian pathogen for prolonged intracellular survival.

    LeVier K, Phillips RW, Grippe VK, Roop RM 2nd, Walker GC.

    Source

    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

    Abstract

    Brucella abortus, a mammalian pathogen, and Rhizobium meliloti, a phylogenetically related plant symbiont, establish chronic infections in their respective hosts. Here a highly conserved B. abortus homolog of the R. meliloti bacA gene, which encodes a putative cytoplasmic membrane transport protein required for symbiosis, was identified. An isogenic B. abortus bacA mutant exhibited decreased survival in macrophages and greatly accelerated clearance from experimentally infected mice compared to the virulent parental strain. Thus, the bacA gene product is critical for the maintenance of two very diverse host-bacterial relationships.

    PMID:
    10741969
    [PubMed - indexed for MEDLINE]

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