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Postgrad Med J. 2000 Apr;76(894):199-206.

Primary biliary cirrhosis: new perspectives in diagnosis and treatment.

Author information

  • 1Centre for Liver Research, University of Newcastle, UK.

Abstract

Primary biliary cirrhosis (PBC) is a chronic autoimmune disease characterised by cholestatic liver function tests, antimitochondrial antibodies, and abnormal liver histology. Early descriptions of a rare rapidly progressive disease no longer reflect the more indolent progress often seen today. Many patients have significant long term morbidity through symptoms such as fatigue and itch with a minority progressing to liver failure and need for transplantation. The current data on the diagnosis, clinical progression, and treatment of PBC are reviewed.

PMID:
10727561
[PubMed - indexed for MEDLINE]
PMCID:
PMC1741548
Free PMC Article
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