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Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4309-14.

Influenza A and B viruses expressing altered NS1 proteins: A vaccine approach.

Author information

  • 1Department of Microbiology, Mount Sinai School of Medicine, Box 1124, One Gustave L. Levy Place, New York, NY 10029, USA.

Abstract

We propose a rational approach to the generation of live viral vaccines: alteration of virally encoded type I IFN antagonists to attenuate virulence while retaining immunogenicity. We have explored this concept by using the influenza virus. Previously we have shown that the NS1 protein of influenza A virus possesses anti-IFN activity. We now present evidence that influenza A and B viruses encoding altered viral NS1 proteins are highly attenuated in the mouse host, yet provide protection from challenge with wild-type viruses.

PMID:
10725408
[PubMed - indexed for MEDLINE]
PMCID:
PMC18238
Free PMC Article
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