Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Psychol Med. 2000 Jan;30(1):117-25.

Quantitative MRI of the hippocampus and amygdala in severe depression.

Author information

  • 1Department of Clinical Neurophysiology, University Hospital of Kuopio, Finland.

Abstract

BACKGROUND:

There is little evidence to support possible structural changes in the amygdala and hippocampus of patients with severe depression.

METHODS:

Quantitative MRI of the amygdala and hippocampus, as well as proton spectroscopy (MRS) of mesial temporal structures were studied in 34 drug-resistant in-patients with major depression and compared with 17 age-matched controls. Volumetric MRI data were normalized for brain size.

RESULTS:

The volume of the left hippocampus was significantly smaller in the patients compared with the controls. Both groups exhibited similar significant hippocampal asymmetry (left smaller than right). The patients, but not the controls, had significant asymmetry of the amygdalar volumes (right smaller than left). No differences were observed between the patients and controls in the T2 relaxation times for the hippocampus and amygdala. Mesial temporal lobe MRS revealed a significantly elevated choline/creatine ratio in the patients compared with the controls.

CONCLUSIONS:

This quantitative MRI study provides support for a possible association between structural and biochemical substrates and severe drug-resistant major depression.

PMID:
10722182
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk