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J Bacteriol. 2000 Apr;182(7):1834-43.

The Yersinia pestis YscY protein directly binds YscX, a secreted component of the type III secretion machinery.

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  • 1Department of Microbiology and Immunology, University of Miami School of Medicine, Miami, Florida 33101, USA.


Human pathogenic yersiniae organisms export and translocate the Yop virulence proteins and V antigen upon contact with a eukaryotic cell. Yersinia pestis mutants defective for production of YscX or YscY were unable to export the Yops and V antigen. YscX and YscY were both present in the Y. pestis cell pellet fraction; however, YscX was also found in the culture supernatant. YscY showed structural and amino acid sequence similarities to the Syc family of proteins. YscY specifically recognized and bound to a region of YscX that included a predicted coiled-coil region. These data suggest that YscY may function as a chaperone for YscX in Y. pestis.

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