Campylobacter jejuni lipopolysaccharides from Guillain-Barré syndrome patients induce IgG anti-GM1 antibodies in rabbits

C W Ang; H P Endtz; B C Jacobs; J D Laman; M A de Klerk; F G van der Meché; P A van Doorn

doi:10.1016/s0165-5728(99)00279-9

Campylobacter jejuni lipopolysaccharides from Guillain-Barré syndrome patients induce IgG anti-GM1 antibodies in rabbits

J Neuroimmunol. 2000 May 1;104(2):133-8. doi: 10.1016/s0165-5728(99)00279-9.

Authors

C W Ang¹, H P Endtz, B C Jacobs, J D Laman, M A de Klerk, F G van der Meché, P A van Doorn

Affiliation

¹ Department of Neurology, Erasmus University Rotterdam, P.O. Box 1738, 3000 DR, Rotterdam, The Netherlands.

PMID: 10713352
DOI: 10.1016/s0165-5728(99)00279-9

Abstract

Lipopolysaccharides (LPS) from Campylobacter jejuni strains isolated from patients with Guillain-Barré syndrome (GBS) display molecular mimicry with GM1. We immunized rabbits with C. jejuni LPS from GBS-associated strains containing a GM1-like epitope. All animals produced high titre anti-LPS antibodies that were cross-reactive with GM1. We conclude that C. jejuni strains from GBS patients are able to induce antibodies that cross-react with gangliosides and LPS. This study further confirms the role of molecular mimicry in the induction of anti-ganglioside antibodies in GBS patients.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antibodies / blood*
Antibody Formation
Campylobacter jejuni*
Disease Models, Animal
Epitopes
G(M1) Ganglioside / immunology*
G(M2) Ganglioside / immunology*
Guillain-Barre Syndrome / immunology*
Humans
Immunization
Immunoglobulin G / blood*
Immunoglobulin M / blood
Lipopolysaccharides / immunology
Lipopolysaccharides / pharmacology*
Rabbits
Time Factors

Substances

Antibodies
Epitopes
Immunoglobulin G
Immunoglobulin M
Lipopolysaccharides
G(M2) Ganglioside
G(M1) Ganglioside