Zhonghua Gan Zang Bing Za Zhi. 2000 Feb;8(1):12-4.

[Cloning and sequence analysis of human genomic DNA of augmenter of liver regeneration hepatitis].

[Article in Chinese]

Cheng J, Zhong Y.

Source

Gene Therapy Research Center, Institute of Infectious Diseases, the 302 Hospital of PLA, Beijing 100039, China.

Abstract

OBJECTIVE:

To clone the human genomic DNA of augmenter of liver regeneration (ALR) and specify the intron-exon structure.

METHODS:

Using human ALR cDNA sequence as a reference and BLAST path as a nucleotide homology search tool, GenBank has been searched for ALR homologous genomic DNA sequence. The intron-exon sequences were defined by the Breathnath-Chambon rule.

RESULTS:

The coding sequence of human ALR consists of 3 exons, and is similar to murine ALR genomic DNA structure. The human ALR genomic DNA is 1813 nt long and codes a protein of 125 amino acid residues.

CONCLUSION:

Human genomic DNA of ALR consists of 3 exons and 2 introns.

PMID:: 10712775; [PubMed - indexed for MEDLINE]

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