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Trends Microbiol. 2000 Mar;8(3):120-8.

Phages will out: strategies of host cell lysis.

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  • 1Dept of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843-2128, USA.


Most phages accomplish host lysis using a muralytic enzyme, or endolysin, and a holin, which permeabilizes the membrane at a programmed time and thus controls the length of the vegetative cycle. By contrast, lytic single-stranded RNA and DNA phages accomplish lysis by producing a single lysis protein without muralytic activity.

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