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Transplantation. 2000 Feb 15;69(3):436-9.

Influenza virus immunization effectivity in kidney transplant patients subjected to two different triple-drug therapy immunosuppression protocols: mycophenolate versus azathioprine.

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  • 1Servicio de Nefrología, Hospital Clínico San Carlos, Universidad Complutense, Madrid, Spain. cfernand@hcsc.es

Abstract

BACKGROUND:

Due to possible complications and treatment limitations, the prevention of influenza in renal transplant (RT) patients is highly indicated.

METHODS:

Forty-nine patients with a 1-year functioning RT subjected to two different immunosuppressive regimens and 37 healthy relatives (HR) were administered the anti-influenza vaccine as recommended for 1996 to 1997. Anti-influenza antibody, creatinine, and immunological markers were estimated at 1 and 3 months after vaccination.

RESULTS:

Three months after vaccination, 46.2% of the RT patients and 69% of the HR (P=0.06) showed protective antibody titers to influenza A (relative risk [RR]; 0.67; 95% confidence interval: 0.44-1.02). A total of 20.5% of the RT patients and 44.8% of the HR showed antibodies to influenza B (P=0.03). Despite these differences, the incidence of illness was similar. The immunosuppressive regimen had no effect on the antibody response.

CONCLUSIONS:

Although the RT patients showed a reduced antibody response, no negative effects on graft outcome were observed.

PMID:
10706057
[PubMed - indexed for MEDLINE]
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