Abstract
The M-CSF receptor (M-CSFR) is expressed in monocytes-macrophages and their progenitors, and drives growth and development of this blood cell lineage. The M-CSFR is a member of a small family of growth factor receptors exhibiting related structures but distinct tissue-specific functions. This review discusses the early molecular events in the M-CSF signaling mechanisms, positive signals, negative signals, the possible organization of individual signaling pathways, and the problem of achieving specificity in the signal transduction mechanism.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, P.H.S.
-
Review
MeSH terms
-
Animals
-
Hematopoiesis / physiology*
-
Humans
-
Macrophages / metabolism
-
Models, Biological
-
Monocytes / metabolism
-
Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases
-
Phosphoric Monoester Hydrolases / metabolism
-
Phosphorylation
-
Receptor, Macrophage Colony-Stimulating Factor / metabolism*
-
Signal Transduction / physiology*
Substances
-
Receptor, Macrophage Colony-Stimulating Factor
-
Phosphoric Monoester Hydrolases
-
INPPL1 protein, human
-
Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases