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Curr Biol. 2000 Feb 24;10(4):R167-9.

Cell death: drosophila Apaf-1 - no longer in the (d)Ark.

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  • Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA. kristin.white@CBRC2.MGH.Harvard.edu


The recent discovery and characterization of Ark, the Drosophila homolog of the mammalian cell-death adaptor protein Apaf-1, have revealed that, like Apaf-1, this protein is important in multiple apoptosis pathways. The new findings also suggest that cell death in flies is very similar to that in mammals after all.

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