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Front Biosci. 2000 Jan 1;5:D30-49.

Pathogenesis and treatment of HIV-1 infection: recent developments (Y2K update).

Author information

  • 1Department of Microbiology and Immunology, 2 Cancer Center, University of Rochester Medical Center, Rochester NY 14642, USA. stephen_dewhurst@urmc.rochester.edu


Human immunodeficiency virus type 1 (HIV-1) is the etiologic agent of acquired immunodeficiency syndrome (AIDS). The pathogenesis of HIV-1-induced disease is complex and characterized by the interplay of both viral and host factors, which together determine the outcome of infection. An improved understanding of the pathogenic mechanisms of AIDS, combined with recent insights into the dynamics of viral infection may provide powerful new opportunities for therapeutic intervention against this virus.

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