J Med Ethics. 2000 Feb;26(1):37-43.

Ethical considerations in international HIV vaccine trials: summary of a consultative process conducted by the Joint United Nations Programme on HIV/AIDS (UNAIDS).

Source

Department of Family Medicine, McMaster University, Hamilton, Canada.

Abstract

Research that is initiated, designed or funded by sponsor agencies based in countries with relatively high social and economic development, and conducted in countries that are relatively less developed, gives rise to many important ethical challenges. Although clinical trials of HIV vaccines began ten years ago in the US and Europe, an increasing number of trials are now being conducted or planned in other countries, including several that are considered "developing" countries. Safeguarding the rights and welfare of individuals participating as research subjects in developing countries is a priority. In September, 1997, the Joint United Nations Programme on HIV/AIDS (UNAIDS) embarked on a process of international consultation; its purpose was further to define the important ethical issues and to formulate guidance that might facilitate the ethical design and conduct of HIV vaccine trials in international contexts. This paper summarises the major outcomes of the UNAIDS consultative process.

PMID:: 10701170; [PubMed - indexed for MEDLINE]
PMCID:: PMC1733173

Free PMC Article

LinkOut - more resources

Full Text Sources

Medical

Supplemental Content

Save items

Related citations in PubMed

The highest attainable standard: ethical issues in AIDS vaccines. [Science. 1998]
The highest attainable standard: ethical issues in AIDS vaccines.
Bloom BR. Science. 1998 Jan 9; 279(5348):186-8.
Microbicide research in developing countries: have we given the ethical concerns due consideration? [BMC Med Ethics. 2007]
Microbicide research in developing countries: have we given the ethical concerns due consideration?
Moodley K. BMC Med Ethics. 2007 Sep 19; 8:10. Epub 2007 Sep 19.
Executive summary and recommendations from WHO/UNAIDS and AAVP consultation on: 'The inclusion of adolescents in HIV vaccine trials', 16-18 March 2006 in Gaborone, Botswana. [AIDS. 2007]
Executive summary and recommendations from WHO/UNAIDS and AAVP consultation on: 'The inclusion of adolescents in HIV vaccine trials', 16-18 March 2006 in Gaborone, Botswana.
WHO/UNAIDS/AAVP International Expert Group, Osmanov S. AIDS. 2007 Sep 12; 21(14):W1-10.
Review Who is my brother's keeper? [J Med Ethics. 2002]
Review Who is my brother's keeper?
Kottow MH. J Med Ethics. 2002 Feb; 28(1):24-7.
Review HIV research, ethics, and the developing world. [Am J Public Health. 1998]
Review HIV research, ethics, and the developing world.
Faden R, Kass N. Am J Public Health. 1998 Apr; 88(4):548-50.

See reviews... See all...

Cited by 7 PubMed Central articles

HIV/AIDS Vaccine: An Update. [Indian J Community Med. 2010]
HIV/AIDS Vaccine: An Update.
Nath A. Indian J Community Med. 2010 Apr; 35(2):222-5.
How informed is consent in vulnerable populations? Experience using a continuous consent process during the MDP301 vaginal microbicide trial in Mwanza, Tanzania. [BMC Med Ethics. 2010]
How informed is consent in vulnerable populations? Experience using a continuous consent process during the MDP301 vaginal microbicide trial in Mwanza, Tanzania.
Vallely A, Lees S, Shagi C, Kasindi S, Soteli S, Kavit N, Vallely L, McCormack S, Pool R, Hayes RJ, et al. BMC Med Ethics. 2010 Jun 13; 11:10. Epub 2010 Jun 13.
Are women who work in bars, guesthouses and similar facilities a suitable study population for vaginal microbicide trials in Africa? [PLoS One. 2010]
Are women who work in bars, guesthouses and similar facilities a suitable study population for vaginal microbicide trials in Africa?
Vallely A, Hambleton IR, Kasindi S, Knight L, Francis SC, Chirwa T, Everett D, Shagi C, Cook C, Barberousse C, et al. PLoS One. 2010 May 14; 5(5):e10661. Epub 2010 May 14.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Ethical considerations in international HIV vaccine trials: summary of a consult...
Ethical considerations in international HIV vaccine trials: summary of a consultative process conducted by the Joint United Nations Programme on HIV/AIDS (UNAIDS).
J Med Ethics. 2000 Feb ;26(1):37-43.

PubMed
Dissecting the role of molecular motors in the mitotic spindle.
Dissecting the role of molecular motors in the mitotic spindle.
Anat Rec. 2000 Feb 15 ;261(1):14-24.

PubMed
Effects of stress reduction on carotid atherosclerosis in hypertensive African A...
Effects of stress reduction on carotid atherosclerosis in hypertensive African Americans.
Stroke. 2000 Mar ;31(3):568-73.

PubMed
Role of protein-solvent interactions in refolding: effects of cosolvent additive...
Role of protein-solvent interactions in refolding: effects of cosolvent additives on the renaturation of porcine pancreatic elastase at various pHs.
Arch Biochem Biophys. 2000 Mar 15 ;375(2):220-8.

PubMed
Mouse mutants from chemically mutagenized embryonic stem cells.
Mouse mutants from chemically mutagenized embryonic stem cells.
Nat Genet. 2000 Mar ;24(3):318-21.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Ethical considerations in international HIV vaccine trials: summary of a consultative process conducted by the Joint United Nations Programme on HIV/AIDS (UNAIDS).

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Medical

Supplemental Content

Save items

Related citations in PubMed

Cited by 7 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information