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1: J Pharm Biomed Anal. 1999 May;19(6):911-5.Click here to read Links

A phosphate binding assay for sevelamer hydrochloride by ion chromatography.

Mazzeo JR, Peters RM, Hanus MR, Chen X, Norton KA.

GelTex Pharmaceuticals, Waltham, MA 02154, USA. www.geltex.com.

Sevelamer hydrochloride is a cross-linked polymeric amine; it is the active ingredient of Renagel capsules. Renagel is indicated for the control of hyperphosphatemia in patients with end-stage renal disease. An in vitro phosphate-binding assay is required to measure the drug's efficacy. The assay developed for this purpose involves mixing the drug (polymer) with a solution of known phosphate concentration, filtering off the polymer-phosphate complex, and quantitating the unbound phosphate concentration by ion chromatography. The binding capacity, reported as mmol of phosphate bound g of polymer(-1), is calculated from the calculated amount of bound phosphate and the weight of polymer used. The method has been validated for accuracy, precision, linearity, range, and ruggedness.

PMID: 10698557 [PubMed - indexed for MEDLINE]

Patient Drug Information

  • Sevelamer (Renagel® )

    Sevelamer is used to treat high blood levels of phosphorous in patients with kidney disease who are on dialysis. It binds phosphorous that you get from foods in your diet and prevents it from being absorbed into your blo...

  • Source: AHFS Consumer Medication Information