Pediatr Clin North Am. 2000 Feb;47(1):65-78.

Viral and immunopathogenesis of vertical HIV-1 infection.

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Department of Pediatrics, University of Massachusetts Medical School, Worcester, USA. katherine.luzuriaga@ummed.edu

Abstract

High-level viral replication is the primary determinant of CD4 depletion or disease development in HIV-1--infected children. The developing immune system of infants might allow for more efficient viral replication and less efficient immune containment of viral replication. Advances in the understanding of the pathogenesis of vertical HIV-1 infection suggest that the use of potent combination regimens to control HIV-1 replication offers the best opportunity to prevent or reverse the sequelae of HIV-1 infection.

PMID:: 10697642; [PubMed - indexed for MEDLINE]

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Cited by 1 PubMed Central article

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