Abstract
The soxRS response, which protects cells against superoxide toxicity, is triggered by the oxidation of SoxR, a transcription factor. Superoxide excess and NADPH depletion induce the regulon. Unexpectedly, we found that the overproduction of desulfoferrodoxin, a superoxide reductase from sulfate-reducing bacteria, also induced this response. We suggest that desulfoferrodoxin interferes with the reducing pathway that keeps SoxR in its inactive form.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Bacterial Proteins / genetics
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Bacterial Proteins / metabolism*
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Escherichia coli / enzymology
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Escherichia coli / genetics
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Escherichia coli Proteins*
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Ferredoxins / metabolism*
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Gene Expression Regulation, Bacterial*
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NADP / metabolism
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Plasmids / genetics
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Regulon*
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Superoxide Dismutase / metabolism
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Superoxides / metabolism
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Trans-Activators*
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Transcription Factors / genetics
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Transcription Factors / metabolism*
Substances
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Bacterial Proteins
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Escherichia coli Proteins
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Ferredoxins
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Trans-Activators
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Transcription Factors
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desulfoferrodoxin
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Superoxides
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SoxR protein, Bacteria
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SoxS protein, E coli
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NADP
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Superoxide Dismutase