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Histopathology. 2000 Mar;36(3):224-8.

Multinucleated stromal cells of the anal mucosa: a common finding.

Author information

  • 1Department of Pathology, Hillel-Yaffe Medical Center, Hadera, Israel.

Abstract

AIMS:

To document the presence, morphology, immunophenotype and ultrastructure of multinucleated stromal cells within the anal mucosa and to discuss possible pathogenetic mechanisms for this occurrence.

METHODS AND RESULTS:

Multiple sections of normal anal mucosa from 30 abdominoperineal resection specimens were analysed by light microscopic, electron microscopic and immunohistochemical methods. Multinucleated stromal cells were found in 22 cases (73%). They contained two to five nuclei, arranged in a linear fashion or in a rosette or grape-like pattern. They stained positive for vimentin and negative for actin, desmin and oestrogen/progesterone receptors. Ultrastructural examination confirmed their fibroblastic lineage. Mast cells were frequently observed in the immediate vicinity of mono- and multinucleated cells.

CONCLUSIONS:

Multinucleated stromal cells are a common occurrence in the normal anal mucosa. They should not be misinterpreted as neoplastic cells. Mast cells may play a role in their morphogenesis.

Comment in

  • Multinucleated stromal cells. [Histopathology. 2000]
PMID:
10692024
[PubMed - indexed for MEDLINE]
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