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Immunol Today. 2000 Mar;21(3):148-54.

Tyrosine kinase SYK: essential functions for immunoreceptor signalling.

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  • 1Molecular Immunology Programme, The Babraham Institute, Cambridge, UK CB2 4AT.


The tyrosine kinase SYK plays critical roles in signalling through immune receptors. Gene-targeting studies have identified the cell types that require SYK for development and function, and the receptors that use SYK as well as their downstream signalling effectors. There is also evidence of a role for SYK in non-immune cells and in the maintenance of vascular integrity.

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