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Immunol Today. 2000 Mar;21(3):129-32.

Heat shock proteins, tumor immunogenicity and antigen presentation: an integrated view.

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  • 1Dept of Medicine, University of Pennsylvania, USA.


A broad range of studies has established that heat shock proteins (Hsps) potentially play a role in tumor immunosurveillance. Here, Andrew Wells and Miroslav Malkovsky highlight recent data that demonstrate a causal relationship between the expression of Hsps and tumor immunogenicity, and suggest several mechanisms by which Hsps might influence the capacity of a tumor to induce an immune response.

[PubMed - indexed for MEDLINE]
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