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    Science. 2000 Feb 25;287(5457):1427-30.

    Out of Eden: stem cells and their niches.

    Watt FM, Hogan BL.

    Source

    Keratinocyte Laboratory, Imperial Cancer Research Fund, 44 Lincoln's Inn Fields, London WC2A 3PX, UK.

    Abstract

    Stem cells are currently in the news for two reasons: the successful cultivation of human embryonic stem cell lines and reports that adult stem cells can differentiate into developmentally unrelated cell types, such as nerve cells into blood cells. Both intrinsic and extrinsic signals regulate stem cell fate and some of these signals have now been identified. Certain aspects of the stem cell microenvironment, or niche, are conserved between tissues, and this can be exploited in the application of stem cells to tissue replacement therapy.

    PMID:
    10688781
    [PubMed - indexed for MEDLINE]

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