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Gynecol Oncol. 2000 Mar;76(3):413-5.

Ovarian cancer in female-to-male transsexuals: report of two cases.

Author information

  • 1Department of Plastic and Reconstructive Surgery, Academisch Ziekenhuis Vrije Universiteit, Amsterdam, The Netherlands. J.JorisHage@inter.nl.net

Abstract

BACKGROUND:

Ovarium cancer is the fifth most common cause of cancer-related death in women and is the most common fatal gynecologic malignancy. So far, ovarium carcinoma has not been reported to have occurred in female-to-male transsexuals.

OBJECTIVE AND METHOD:

We report on two such cases. Long-term exposure to increased levels of endogenous and exogenous androgens is hypothesized to constitute an additional risk factor in transsexuals as it has been associated with ovarian epithelian cancer.

CONCLUSION:

Simultaneous salpingo-oophorectomy should be performed in any female-to-male transsexual undergoing hysterectomy in the course of gender-confirming therapy.

Copyright 2000 Academic Press.

PMID:
10684720
[PubMed - indexed for MEDLINE]
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