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Curr Opin Immunol. 2000 Feb;12(1):114-21.

The control of T cell responses by dendritic cell subsets.

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  • 1Roche Milano Ricerche, Milan, 20132, Italy.


Dendritic cells are known as the most efficient antigen-presenting cell type to activate naïve T cells; however, they are able to do more than just efficiently present antigen to T cells. They are key modulators of the immune response that can influence Th cell differentiation by preferentially inducing Th type 1 or 2 cell responses, and the differential polarisation of CD4(+) T cells appears to be mediated by discrete dendritic cell subsets.

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  • Antigen recognition. [Curr Opin Immunol. 2000]
[PubMed - indexed for MEDLINE]
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