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Curr Opin Chem Biol. 2000 Feb;4(1):103-9.

Oxynitrilases for asymmetric C-C bond formation.

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  • 1Spezialforschungsbereich Biokatalyse, Institut für Organische Chemie der Technischen Universität Graz, Graz, A-8010, Austria.

Abstract

Oxynitrilases for the preparation of (R)- or (S)-cyanohydrins are now readily available. The research efforts of a number of groups have established these enzymes as catalysts with significant potential for application to asymmetric synthesis. Advances made in molecular cloning and genetics have delivered information on the oxynitrilase mechanism of action and sufficient quantities of enzyme to satisfy industrial requirements.

PMID:
10679367
[PubMed - indexed for MEDLINE]
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