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Curr Opin Cell Biol. 2000 Feb;12(1):97-103.

Control of actin assembly and disassembly at filament ends.

Author information

  • 1Department of Cell Biology, Washington University, Box 8228, St Louis, MO 631110, USA. jcooper@cellbio.wustl.edu

Abstract

The most important discovery in the field is that the Arp2/3 complex nucleates assembly of actin filaments with free barbed ends. Arp2/3 also binds the sides of actin filaments to create a branched network. Arp2/3's nucleation activity is stimulated by WASP family proteins, some of which mediate signaling from small G-proteins. Listeria movement caused by actin polymerization can be reconstituted in vitro using purified proteins: Arp2/3 complex, capping protein, actin depolymerizing factor/cofilin, and actin. actin depolymerizing factor/cofilin increases the rate at which actin subunits leave pointed ends, and capping protein caps barbed ends.

PMID:
10679358
[PubMed - indexed for MEDLINE]
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