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Heart. 2000 Mar;83(3):338-45.

Biocompatibility of phosphorylcholine coated stents in normal porcine coronary arteries.

Author information

  • 1Department of Cardiology, Thoraxcenter, Erasmus University Rotterdam, PO Box 1738, 3000 DR Rotterdam, The Netherlands.

Abstract

OBJECTIVE:

To improve the biocompatibility of stents using a phosphorylcholine coated stent as a form of biomimicry.

INTERVENTIONS:

Implantation of phosphorylcholine coated (n = 20) and non-coated (n = 21) stents was performed in the coronary arteries of 25 pigs. The animals were killed after five days (n = 6), four weeks (n = 7), and 12 weeks (n = 8), and the vessels harvested for histology, scanning electron microscopy, and morphometry.

MAIN OUTCOME MEASURES:

Stent performance was assessed by studying early endothelialization, neointima formation, and vessel wall reaction to the synthetic coating.

RESULTS:

Stent thrombosis did not occur in either group. Morphometry showed no significant differences between the two study groups at any time point. At five days both the coated and non-coated stents were equally well endothelialised (91% v 92%, respectively). At four and 12 weeks there was no difference in intimal thickness between the coated and non-coated stents. Up to 12 weeks postimplant the phosphorylcholine coating was still discernible in the stent strut voids, and did not appear to elicit an adverse inflammatory response.

CONCLUSION:

In this animal model the phosphorylcholine coating showed excellent blood and tissue compatibility, unlike a number of other polymers tested in a similar setting. Given that the coating was present up to 12 weeks postimplant with no adverse tissue reaction, it may be a potential candidate polymer for local drug delivery.

PMID:
10677417
[PubMed - indexed for MEDLINE]
PMCID:
PMC1729350
Free PMC Article
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