Source
Fellow of Infectious Diseases, College of Pharmacy, University of Oklahoma, Oklahoma City, USA. pclay@cctr.umkc.edu
Abstract
OBJECTIVE:
To develop an abacavir hypersensitivity reaction management protocol for the University of Oklahoma Health Sciences Center.
DATA SYNTHESIS:
Conference abstracts, published literature, and manufacturer-provided materials were reviewed to define the syndrome and manifestations and to recommend steps to take when a patient develops abacavir-related reactions.
RESULTS:
Initial education, formalized contact and response mechanism, and intervention levels were incorporated into a protocol for clinicians.
CONCLUSIONS:
Abacavir, a newly approved agent for the treatment of HIV, has been associated with a fatal hypersensitivity reaction. Our protocol provides a mechanism to minimize progression of abacavir hypersensitivity reaction by providing a formalized management procedure.