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Ann Pharmacother. 2000 Feb;34(2):247-9.

Management protocol for abacavir-related hypersensitivity reaction.

Author information

  • 1Fellow of Infectious Diseases, College of Pharmacy, University of Oklahoma, Oklahoma City, USA. pclay@cctr.umkc.edu

Abstract

OBJECTIVE:

To develop an abacavir hypersensitivity reaction management protocol for the University of Oklahoma Health Sciences Center.

DATA SYNTHESIS:

Conference abstracts, published literature, and manufacturer-provided materials were reviewed to define the syndrome and manifestations and to recommend steps to take when a patient develops abacavir-related reactions.

RESULTS:

Initial education, formalized contact and response mechanism, and intervention levels were incorporated into a protocol for clinicians.

CONCLUSIONS:

Abacavir, a newly approved agent for the treatment of HIV, has been associated with a fatal hypersensitivity reaction. Our protocol provides a mechanism to minimize progression of abacavir hypersensitivity reaction by providing a formalized management procedure.

PMID:
10676833
[PubMed - indexed for MEDLINE]
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