The molecular biology and regulation of 5-lipoxyge...[Am J Respir Crit Care Med. 2000]

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1: Am J Respir Crit Care Med. 2000 Feb;161(2 Pt 2):S11-5. Links

The molecular biology and regulation of 5-lipoxygenase.

Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden. Olof.Radmark@mbb.ki.se

PMID: 10673219 [PubMed - indexed for MEDLINE]

1,25-Dihydroxyvitamin D3 upregulates 5-lipoxygenase metabolism and 5-lipoxygenase activating protein in peripheral blood monocytes as they differentiate into mature macrophages.
J Lipid Mediat. 1993 Mar-Apr; 6(1-3):43-51.

[J Lipid Mediat. 1993]
The effect of 5-lipoxygenase-activating protein (FLAP) on substrate utilization by 5-lipoxygenase.
Adv Exp Med Biol. 1997; 400A:145-51.

[Adv Exp Med Biol. 1997]
ReviewArachidonate 5-lipoxygenase.
Prostaglandins Other Lipid Mediat. 2002 Aug; 68-69:211-34.

[Prostaglandins Other Lipid Mediat. 2002]
Review5-lipoxygenase and FLAP.
Prostaglandins Leukot Essent Fatty Acids. 2003 Aug-Sep; 69(2-3):99-109.

[Prostaglandins Leukot Essent Fatty Acids. 2003]
ReviewRegulation of the biosynthesis of the sulphido-leukotrienes.
Adv Exp Med Biol. 1997; 400B:841-7.

[Adv Exp Med Biol. 1997]
» See reviews... | » See all...

The shunt from the cyclooxygenase to lipoxygenase pathway in human osteoarthritic subchondral osteoblasts is linked with a variable expression of the 5-lipoxygenase-activating protein.
Maxis K, Delalandre A, Martel-Pelletier J, Pelletier JP, Duval N, Lajeunesse D. Arthritis Res Ther. 2006; 8(6):R181.

[Arthritis Res Ther. 2006]
Convergent oxygenation of arachidonic acid by 5-lipoxygenase and cyclooxygenase-2.
Schneider C, Boeglin WE, Yin H, Stec DF, Voehler M. J Am Chem Soc. 2006 Jan 25; 128(3):720-1.

[J Am Chem Soc. 2006]
Membrane fluidity is a key modulator of membrane binding, insertion, and activity of 5-lipoxygenase.
Pande AH, Qin S, Tatulian SA. Biophys J. 2005 Jun; 88(6):4084-94. Epub 2005 Mar 18.

[Biophys J. 2005]
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