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Science. 2000 Feb 11;287(5455):1060-2.

Evidence for DNA loss as a determinant of genome size.

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  • 1Harvard University Society of Fellows, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA. dpetrov@oeb.harvard.edu

Abstract

Eukaryotic genome sizes range over five orders of magnitude. This variation cannot be explained by differences in organismic complexity (the C value paradox). To test the hypothesis that some variation in genome size can be attributed to differences in the patterns of insertion and deletion (indel) mutations among organisms, this study examines the indel spectrum in Laupala crickets, which have a genome size 11 times larger than that of Drosophila. Consistent with the hypothesis, DNA loss is more than 40 times slower in Laupala than in Drosophila.

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PMID:
10669421
[PubMed - indexed for MEDLINE]
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