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Curr Biol. 2000 Jan 27;10(2):R84-7.

RING for destruction?

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  • 1Molecular Structure and Function Laboratory, Imperial Cancer Research Fund, London, WC2A 3PX, UK. freemont@icrf.icnet.uk.

Abstract

Ubiquitination targets proteins for degradation and is a potent regulator of cellular protein function. Recent results implicate the RING finger domain in specific ubiquitination events; it is possible that all RING proteins act as E3 ubiquitin protein ligases, with implications for a variety of biological areas.

PMID:
10662664
[PubMed - indexed for MEDLINE]
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